The time of the Antiquity is a glorious time in the history of Macedonia when kings like Philip II and Alexander III unified the people of the Balkans and conquered the known world. Many archaeological structures and artifacts are found from that period in the area of the ancient city of Lychnidos, Engelana and in the Pelagonia region.

When Macedonia became a Roman province, her location as the crossroad on three important Roman roads allowed the cities of this region, such as Skupi, Stobi, Heraclea Lyncestis, Lychnidos (Ohrid) to develop and enjoy the highest privileges of the Roman Empire.

After declare of the Christian religion as a state religion of the Roman Empire many of the cities in Macedonia became Episcopal centers. The Early Christian Basilicas in Stobi, Luchnidos and Heraclea Lyncestis, with unique mosaic floors and the terracotta icons in Vinica are just some of the proofs that state the importance and the richness of the Macedonian cities in these troubled times.